Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
Identifieur interne : 001D78 ( Main/Exploration ); précédent : 001D77; suivant : 001D79Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
Auteurs : Piero Barbanti ; Giovanni Fabbrini ; Alberto Ricci ; Rosanna Cerbo ; Elena Bronzetti ; Brunella Caronti ; Caterina Calderaro ; Laura Felici ; Fabrizio Stocchi [Italie] ; Giuseppe Meco ; Francesco Amenta [Italie] ; Gian Luigi LenziSource :
- Movement Disorders [ 0885-3185 ] ; 1999-09.
English descriptors
- KwdEn :
Abstract
Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH‐DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1‐like (p <0.001) and D2‐like (p <0.00001) receptors on PBL than either neurologic or healthy control subjects, whereas no differences in Bmax were observed among patients affected by other neurologic diseases and healthy control subjects. The affinity (Kd) of both radioligands was similar in the groups investigated. The pharmacologic profile of [3H]SCH 23390 and [3H]7OH‐DPAT binding was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. Twenty‐five of the 50 patients with PD were retested after 3 months of therapy with levodopa or bromocriptine. Both treatments reduced the density of D1‐like (p <0.001) and D2‐like (p <0.001) receptors on PBL to values comparable to those of control subjects. The increased density of D1‐like and D2‐like receptors on PBL in de novo PD patients may represent an upregulation mechanism resulting from the diffuse impairment of the dopaminergic system in PD.
Url:
DOI: 10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO;2-W
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased expression of dopamine receptors on lymphocytes in Parkinson's disease</title><author><name sortKey="Barbanti, Piero" sort="Barbanti, Piero" uniqKey="Barbanti P" first="Piero" last="Barbanti">Piero Barbanti</name></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></author><author><name sortKey="Ricci, Alberto" sort="Ricci, Alberto" uniqKey="Ricci A" first="Alberto" last="Ricci">Alberto Ricci</name></author><author><name sortKey="Cerbo, Rosanna" sort="Cerbo, Rosanna" uniqKey="Cerbo R" first="Rosanna" last="Cerbo">Rosanna Cerbo</name></author><author><name sortKey="Bronzetti, Elena" sort="Bronzetti, Elena" uniqKey="Bronzetti E" first="Elena" last="Bronzetti">Elena Bronzetti</name></author><author><name sortKey="Caronti, Brunella" sort="Caronti, Brunella" uniqKey="Caronti B" first="Brunella" last="Caronti">Brunella Caronti</name></author><author><name sortKey="Calderaro, Caterina" sort="Calderaro, Caterina" uniqKey="Calderaro C" first="Caterina" last="Calderaro">Caterina Calderaro</name></author><author><name sortKey="Felici, Laura" sort="Felici, Laura" uniqKey="Felici L" first="Laura" last="Felici">Laura Felici</name></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name></author><author><name sortKey="Amenta, Francesco" sort="Amenta, Francesco" uniqKey="Amenta F" first="Francesco" last="Amenta">Francesco Amenta</name></author><author><name sortKey="Lenzi, Gian Luigi" sort="Lenzi, Gian Luigi" uniqKey="Lenzi G" first="Gian Luigi" last="Lenzi">Gian Luigi Lenzi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:96D855F1FBF0045844CED703B6EAF55077826366</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO;2-W</idno><idno type="url">https://api.istex.fr/document/96D855F1FBF0045844CED703B6EAF55077826366/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002075</idno><idno type="wicri:Area/Main/Curation">001D74</idno><idno type="wicri:Area/Main/Exploration">001D78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Increased expression of dopamine receptors on lymphocytes in Parkinson's disease</title><author><name sortKey="Barbanti, Piero" sort="Barbanti, Piero" uniqKey="Barbanti P" first="Piero" last="Barbanti">Piero Barbanti</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Ricci, Alberto" sort="Ricci, Alberto" uniqKey="Ricci A" first="Alberto" last="Ricci">Alberto Ricci</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Cerbo, Rosanna" sort="Cerbo, Rosanna" uniqKey="Cerbo R" first="Rosanna" last="Cerbo">Rosanna Cerbo</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Bronzetti, Elena" sort="Bronzetti, Elena" uniqKey="Bronzetti E" first="Elena" last="Bronzetti">Elena Bronzetti</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Caronti, Brunella" sort="Caronti, Brunella" uniqKey="Caronti B" first="Brunella" last="Caronti">Brunella Caronti</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Calderaro, Caterina" sort="Calderaro, Caterina" uniqKey="Calderaro C" first="Caterina" last="Calderaro">Caterina Calderaro</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Felici, Laura" sort="Felici, Laura" uniqKey="Felici L" first="Laura" last="Felici">Laura Felici</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>I.R.C.C.S. Neuromed, Pozzilli and the Section of Human Anatomy, Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino</wicri:regionArea><wicri:noRegion>Camerino</wicri:noRegion></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author><author><name sortKey="Amenta, Francesco" sort="Amenta, Francesco" uniqKey="Amenta F" first="Francesco" last="Amenta">Francesco Amenta</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Human Anatomy, Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino</wicri:regionArea><wicri:noRegion>Camerino</wicri:noRegion></affiliation></author><author><name sortKey="Lenzi, Gian Luigi" sort="Lenzi, Gian Luigi" uniqKey="Lenzi G" first="Gian Luigi" last="Lenzi">Gian Luigi Lenzi</name><affiliation><wicri:noCountry code="subField">” Rome</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-09">1999-09</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="764">764</biblScope><biblScope unit="page" to="771">771</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">96D855F1FBF0045844CED703B6EAF55077826366</idno><idno type="DOI">10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO;2-W</idno><idno type="ArticleID">MDS1008</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine receptor</term><term>Lymphocyte</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH‐DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1‐like (p <0.001) and D2‐like (p <0.00001) receptors on PBL than either neurologic or healthy control subjects, whereas no differences in Bmax were observed among patients affected by other neurologic diseases and healthy control subjects. The affinity (Kd) of both radioligands was similar in the groups investigated. The pharmacologic profile of [3H]SCH 23390 and [3H]7OH‐DPAT binding was consistent with the labeling of dopamine D5 and D3 receptor subtypes, respectively. Twenty‐five of the 50 patients with PD were retested after 3 months of therapy with levodopa or bromocriptine. Both treatments reduced the density of D1‐like (p <0.001) and D2‐like (p <0.001) receptors on PBL to values comparable to those of control subjects. The increased density of D1‐like and D2‐like receptors on PBL in de novo PD patients may represent an upregulation mechanism resulting from the diffuse impairment of the dopaminergic system in PD.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Barbanti, Piero" sort="Barbanti, Piero" uniqKey="Barbanti P" first="Piero" last="Barbanti">Piero Barbanti</name><name sortKey="Bronzetti, Elena" sort="Bronzetti, Elena" uniqKey="Bronzetti E" first="Elena" last="Bronzetti">Elena Bronzetti</name><name sortKey="Calderaro, Caterina" sort="Calderaro, Caterina" uniqKey="Calderaro C" first="Caterina" last="Calderaro">Caterina Calderaro</name><name sortKey="Caronti, Brunella" sort="Caronti, Brunella" uniqKey="Caronti B" first="Brunella" last="Caronti">Brunella Caronti</name><name sortKey="Cerbo, Rosanna" sort="Cerbo, Rosanna" uniqKey="Cerbo R" first="Rosanna" last="Cerbo">Rosanna Cerbo</name><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><name sortKey="Felici, Laura" sort="Felici, Laura" uniqKey="Felici L" first="Laura" last="Felici">Laura Felici</name><name sortKey="Lenzi, Gian Luigi" sort="Lenzi, Gian Luigi" uniqKey="Lenzi G" first="Gian Luigi" last="Lenzi">Gian Luigi Lenzi</name><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><name sortKey="Ricci, Alberto" sort="Ricci, Alberto" uniqKey="Ricci A" first="Alberto" last="Ricci">Alberto Ricci</name></noCountry><country name="Italie"><noRegion><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></noRegion><name sortKey="Amenta, Francesco" sort="Amenta, Francesco" uniqKey="Amenta F" first="Francesco" last="Amenta">Francesco Amenta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:96D855F1FBF0045844CED703B6EAF55077826366
|texte= Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |